Evaluates the coefficient from the linear regression of s2.post ~ sigmaSq. When there is no shrinkage, this value is 1. Values less than 1 indicate the amount of shrinkage.
Usage
shrinkageMetric(sigmaSq, s2.post)
Arguments
- sigmaSq
maximum likelihood residual variance for every gene
- s2.post
empirical Bayes posterior estimate of residual variance for every gene
Details
Shrinkage metric for eBayes quantifying the amount of shrinkage that is applied to shrink the maximum likelihood residual variance to the empirical Bayes posterior estimate