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Apply pre-specified sample weights

Source: R/applyQualityWeights.R
applyQualityWeights.Rd

Apply pre-specified sample weights by scaling existing precision weights

Usage

applyQualityWeights(vobj, weights)

Arguments

vobj

EList from voom or voomWithDreamWeights.

weights

sample level weights

Details

Apply pre-specified sample-level weights to the existing precision weights estimated from the data. While the limma::voomWithQualityWeights function of Lui et al. (2015) estimates the sample-level weights from voom fit, here the weights are fixed beforehand.

References

Liu R, Holik AZ, Su S, Jansz N, Chen K, Leong HS, Blewitt ME, Asselin-Labat M, Smyth GK, Ritchie ME (2015). “Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses.” Nucleic acids research, 43(15), e97--e97.

See also

limma::voomWithQualityWeights